Favourable Outcome of canceR Therapy (ODR1920_062)

Historical Data Processing

PHE sent the FORTY study team the requested dataset to process as follows:

1) Separate any patients with a death record within 5 years of treatment and

hold as cohort 2

2) Exclude any patients where the treatment intent is not radical using treatment intent codes, event codes and treatment details where intent is incomplete

3) Separate any patients with another treatment record within 5 years (indicating the first round of radical treatment did not cure the cancer) and hold as

cohort 3 using the same data codes as step 2 as well as event dates

4) Count the number of patients remaining, this is our patients cured cohort,

cohort 1

5) Stratify the main cohort (cohort 1) of patients remaining by treatment modality or modalities

Cohort 3 will be sent back to step 1 so patients who were cured with a second (or

more) round of radical treatment are still included in the analysis.

Once cohort 1 has been selected and separated by treatment modalities, the contribution that each modality has to the number of cured patients will be calculated.

For the secondary research questions, cohort 1 will also be separately stratified by:

a) Cancer site

b) Deprivation (IMD quintile)

c) Ethnic group

d) Age group

The data will be transferred from PHE to the UoM research data storage systems via the PHE secure file exchange. If a password is required for the data file then this will be provide via a separate communication line, such as telephone call.

The data will be loaded into a SQL database, held on a University of Manchester research data storage system which meets all requirements specified by any data-sharing agreement between Public Health England and the University of Manchester. The SQL database allows the data to be extracted, filtered and sorted without modifying the data offload from NCRAS, keeping the original data the same as originally received.

Typically for this type of research, we will assume that 'cure' means 5 years of survival following treatment, without tumour recurrence or progression.

The stages of processing the data to achieve the principle research question are as follows:

1) Remove any patients with a death record within 5 years of treatment and hold them separate

2) Remove any patients where the treatment intent is not radical

3) Remove any patients with another treatment record within 5 years (indicating the first round of radical treatment did not cure the cancer)

4) Count the number of patients remaining, this is our patients cured cohort

5) Separate the cohort of patients remaining by treatment modality or modalities

Once the final cohort of patients has been selected and separated by treatment modalities, the contribution that each modality has to the number of cured patients will be calculated.

For the secondary research questions, the main results from step 5 will be separately stratified by:

a) Cancer site

b) Deprivation (IMD quintile)

c) Ethnic group

d) Age group

Additionally, the patients that have a death record will be further analysed to identify any potential cohorts that died within 6 months of radical intent treatment.

Journal Publications and conference presentations

Scientific publications and conference abstracts. Updating the available data and making it more rigorous and measurable

Abstracts at Scientific conferences