MR529 - Early Life Origins of Insulin Resistance

This project is designed to further understanding of the insulin resistance syndrome (syndrome X) which is characterised by impaired glucose tolerance, hypertension, elevated serum triglycerides and central adiposity, in relation to a range of risk factors acting throughout foetal development and during infancy and early childhood.

The research will involve tracing and conducting a follow up clinical examination and questionnaire survey on a group of 951 offspring of pregnant women who were enrolled in to a dietary supplementation trial in South Wales between 1972 and 1974.

Re contacting this cohort will allow antenatal maternal factors, indicators of foetal development, growth from birth to age five, infant feeding practices, illness during the first five years of life, socio-economic factors and blood pressure at age 5 to be related to the development of components of syndrome X in early adulthood.

The study will represent a considerable advance over previous investigations which have in general focused solely on post-natal measures such as birth weight and weight at one year or adult determinants of disease risk.

This cohort will be able to extend our understanding to both pre-natal and early childhood factors the may either directly influence risk of developing non-insulin dependant diabetes mellitus or interact with later risk factors such as adult body mass index and fat distribution.

Not stated in the register.

Not stated in the register.

Not stated in the register.

Yielded Benefits is not a requirement for new applications.